Skip to content

My Experience With Doxiderol

2012 October 1
by Aaron


I was recently contacted about sampling and writing a review about Doxiderol, a brain supplement, manufactured by Mentis Laboratories. As some of you probably could guess, I loved the movie Limitless, and I have been interested in nootropics ever since. This is my first experience with any sort of memory or focus enhancers, so I don’t have anything to compare Doxiderol to, but I can say that I had an overall positive experience.

If you didn’t know, a nootropic is a type of cognitive enhancer that is non-toxic. I want to make this important distinction, because I know many college and graduate students use Adderall, Ritalin, etc. without a prescription in order to study longer/better. I am sure that these drugs probably work…however, I would never ingest or recommend something that could do damage to my body. Nor would I take a controlled substance without a prescription. I said yes to trying Doxiderol because it contains vitamins and supplements. I feel no worse about taking these than I do about taking my protein powder after working out.

I will step off my pedestal and get back to the science! I want to describe a few of the cooler natural compounds found in Doxiderol:

Vitamin B5: We just learned about vitamins and their functions for our first medical school test, so I can tell you all about vitamin B5 (pantothenic acid). It is mostly used to synthesize coenzyme A, which is then used as a precursor to a host of other compounds. Most importantly for our discussion, it is a key component of acetlycholine, a neurotransmitter. Acetylcholine is involved in short-term memory and synaptic plasticity, both important in the learning process.

Vitamin B12: Otherwise known as cobalamin, this vitamin is crucial for cellular metabolism and energy production in every cell of the human body. It is also used to regenerate folic acid. Low levels of vitamin B12 in the blood have been linked to brain shrinkage and poor performances on cognitive tests.

Theanine: An amino acid that can cross the blood brain barrier, and is naturally found in green tea. The FDA recognizes this substance as “safe” and it has been shown to decrease mental and physical stress, improve cognition, and work as a mood-booster. In the brain, it works to increase dopamine levels. Theanine works synergistically with my favorite ingredient in Doxiderol…caffeine!

Caffeine: I think every college student, or pre-med knows and has a good relationship with caffeine. It is obviously a stimulant of the central nervous system (CNS), and increases alertness. It easily crosses the blood brain barrier, where it acts as an antagonist of adenosine – a CNS inhibitor.

On the Doxiderol bottle, Mentis Laboratories recommends taking 2 pills, 30 minutes before studying or class. I didn’t know how I would initially react to taking Doxiderol, so I started with one pill before attending lecture one morning. It took a good bit of time for me to start feeling anything, but within in an hour or so I was wide awake, and the time in class seemed to fly (rather than drag) by. The next day, I wanted to see what 2 Doxiderol capsules before class would do. Within 15-20 minutes I felt a slight buzzing behind my eyes, and it was like a large RedBull had just kicked in. I didn’t bother to finish my morning coffee, as I no longer needed it. I was on my game in class. I was completely in the moment rather than day dreaming or texting.

I used the supplement off and on for the two weeks, mostly to prepare for my first medical school test. I modified my approach with it though and started taking 2 supplements before my afternoon/evening study sessions. We all know how hard it is to study for hours upon hours without losing concentration or checking Facebook or email. On Doxiderol, I actually set a timer to remind myself to take 10 minute breaks every hour. I am sure that some of the effects from Doxiderol are psychosomatic, but my girlfriend had some of the same opinions on this nootropic. She is in dental school, and rarely drinks coffee or anything. Doxiderol seemed to affect her more than me. It really woke her up, and she literally studied for 6-7 hours straight on one dose.

There were a couple of side-effects from Doxiderol, although they were mostly to be expected. One time I took it too closely to bed time, and couldn’t sleep (probably from the caffeine). My girlfriend and I also noticed that after taking it we both experienced a bit of dry-mouth. Not real sure what could causes it but I always remembered to bring a bottle of water with me to the library if I was going to use Doxiderol. I also stopped my coffee consumption while taking the pills, as I didn’t want to become jittery.

All in all, I think Doxiderol helped my studying. It mostly functioned to wake me up, like a big cup of coffee would, but I really did notice an increase in my attention span. It won’t make you smarter, but it may give you an extra boost as you crack the books. Depending on my first test score, I may or not be buying another bottle of the nootropic. I am interested in your experience with Doxiderol or other nootropics. Have they helped you?

Disclosure: I was sent one free sample of Doxiderol, however, I receive no compensation or commission from any sales. 


26 Responses Post a comment
  1. Matt permalink
    October 1, 2012

    Thanks for the review! I’ve actually been using Doxiderol for a few months now. Thought it was my little secret :). Seriously this stuff has saved me when I needed to really study.

    • October 4, 2012

      How long have you been using it Matt? How did you find out about the product? Just curious to see what others think about it. Thanks for the comment!

      • Matt permalink
        October 4, 2012

        I found it on facebook.. I’ve used it for a few months. I find that it gives me a better boost than redbull. I care about my diet and I like how I don’t have to worry sugar or the million calories in a latte. . I also find its faster and more effective than coffee.

  2. Florence permalink
    October 9, 2012

    Hey! To start with youve got a fantastic blog going on. I know this is unrelated, but I wantto ask: When is the earliest time one can start preparing for the MCAT’s? Say… second year of college? Another question-Im currently going for a commerce degree and taking first year chem,bio and physics courses on the side, would that put me at a disadvantage while taking the MCATS/applying? How deep is the knowledge being tested on the mcat
    What degree to do suggest? Only going for commerce in case med school plans crash and burn.


    • October 17, 2012

      You should start preparing for the MCAT 3-4 months prior to your test date. It wouldn’t really help to study for a test when you haven’t even taken all of the courses yet. Your college degree shouldn’t matter as long as you complete the pre-reqs required for medical school.

  3. Jean permalink
    October 13, 2012

    This is a great review of Doxiderol. Thanks for summing it up so efficiently.. I just recently started using it myself and I can tell you for certain it helps me study. Im in medical school so Ive had my fair share of all-nighters. Doxiderol wakes me up and helps me concentrate all night long. I think I may use it all four years of school

  4. December 26, 2012

    Right now I take 2 Dexedrine and 1/2 Caffeine pills a day to put in long productive hours studying for my MCAT. My doctor cringes when I tell him about the caffeine, but I’m young and I am in very good physical condition, so the risk of heart problems is minimal (this is what I am assuming, since he doesn’t tell me explicitly that I shouldn’t).

    I’ve always had a fascination with “mind altering” substances and I have consumed more than my fair share during my youth. I am no pharmacologist but I do know (from wikipedia, god bless) that Dexedrine is an amphetamine that acts on the dopaminergic receptors mimicking dopamine (i.e. very similar structurally) and that it also inhibits the re-uptake of monoamine neurotransmitters (i.e. catecholamine, epinephrine, norepinephrine etc.).

    This Doxiderol aka. Huperzine A, really has piqued my interest. It is an acetylcholinesterase inhibitor, which means that it is acting on the same neurotransmitters as nicotine and cannabis!!! Of course, I’d like to see more clinical studies on its effectiveness.

    This seems particularly attractive since it could be cheaper than what I use now. My main concern, however, is that this product seems kind of “scam-y”. How do I know I am getting a pure product, and not just (potentially harmful) filler, especially since it doesn’t appear to be medically licensed?

    P.S. This blog is great

    • December 26, 2012


      Thanks for the kind words. Unfortunately, the FDA does not regulate or “medically license” any supplements. You sort of have to trust the integrity of a company when buying things like this (or anything at GNC). I think it is worth getting a small bottle and sort of testing it on yourself. I would love to hear what you think about it.


  5. February 1, 2013

    So how did your first exam go?

    Do you think this is a product you can’t go without later, or just an accessory (like coffee)?

    • February 1, 2013

      I actually honored my first exam scoring a 91%. I like Doxiderol, and I ordered a second batch for myself. However, to be honest I don’t use it every single day. However, I do use coffee everyday. I think it really helps, but it is essential to my success.

  6. Elina permalink
    February 7, 2013


    You are absolutely right. Doxiderol is vitamins for memory contains high quality ingredients like Bacopa, Caffeine, Vinpocetine, citicholine etc.

  7. Nelly Lansey permalink
    July 6, 2013

    Theanine has a chemical structure very similar to glutamate, a naturally occurring amino acid in the body that helps transmit nerve impulses in the brain. Some of the effects of theanine appear to be similar to glutamate, and some effects seem to block glutamate.

  8. November 6, 2013


    how did you get the free sample of Doxiderol?

    • December 23, 2013

      Part of the perks of having a mildly successful blog, companies like you to review their products.

  9. Alex permalink
    January 7, 2014

    Have you noticed since taking doxiderol that you cannot concentrate without it almost like withdrawl symptoms or has it not effected you?

    • January 7, 2014

      Hey Alex,

      No I haven’t. After I finished my second bottle of it (sometime well over a year ago), I stopped ordering/taking it. I didn’t really notice any drop off in performance, although I now have 2-3 cups of coffee a day. Studying isn’t always fun, but I just treat it as a full time job and get to work. I don’t think anything in Doxiderol is habit forming at all.


  10. Zaid permalink
    January 21, 2014

    Hi Aaron, thanks for the review. I have been doing my research on doxiderol and everything seems to be to my liking. There is however something similar called profiderall. Do you have any experience with this? I am trying to compare the two but have not be able to gain too much information. Any help is appreciated :)

    • January 21, 2014


      I have not heard of profiderall. To be 100% honest, I use products that are sent to me for free to review on the blog. I also never touch anything that could get me in trouble or be considered “cheating.” I liked that Doxiderol was mostly a combination of vitamins. Check out Reddit and its discussion on nootropics!

      thanks for the comments,


  11. Maddie permalink
    February 17, 2014

    Hey! So I have a quick question. Why did you stop taking Doxiderol? Is this something you would recommend only using to prepare for exams and not for daily use? Thanks!

    • February 19, 2014

      Hey Maddie,

      I stopped taking Doxiderol because I didn’t feel like I needed it to do well. I liked how it worked, but not enough to continuously spend the money on it. I think I would recommend you try it out and see how it works for you as individual results may vary!


  12. Alex permalink
    March 12, 2014

    Hi Aaron,

    Thanks for the review on this product. I’m still waiting for my first bottle in order to give it a shot. What I am really hoping to gain is not more energy boots (that I can get from coffee) but more focus and patience in order to be able to concetrate on a specific set of tasks. Do you think this product would help?
    To me, more energy equals more ADD behavior :)


    • March 31, 2014


      I don’t think that Doxiderol will give you the jitters like caffeine would. I don’t have ADHD or anything of the sort, so you will have to let me know how it works for you!


  13. Dave permalink
    June 9, 2014

    Ive been taking doxideral for 6 days. Improvements in concentration and energy thus far. For me this could be a long term supplement but the question I have is do you know if im likely to build a tolerance and whether or not I should stagger the doses..?

  14. unnamed permalink
    October 22, 2014

    wow! super!

  15. Keena permalink
    January 2, 2015

    Is this sold in NYC/Rite Aid/CVS in United States?

  16. John permalink
    February 20, 2015

    I’m not trying to bash or be a smart-ass (whenever anyone puts something critical on the internet everyone freaks out and thinks a fight is a brewin’) but I just want to point out that you could take a caffeine pill and get the exact same results.

    “But caffeine makes you jittery, etc. etc.” – depends on the dose. Caffeine pills are usually high doses, hence that effect.

    Point being, so far there is nothing to prove that all of the positive effects aren’t just the caffeine and the rest of the ingredients not just window dressing to make it look more legitimate.

Leave a Reply

Note: You may use basic HTML in your comments. Your email address will not be published.

Subscribe to this comment feed via RSS